ABSTRACT
Objective To study the clinical diagnosis,treatment and prognosis of and the factors influencing prognosis of breast cancer(BC) in young women. Methods A restrospective analysis of the clinical data of 59 cases treated from Jan .1990 to Dec. 1998was carried out in the Second Xiangya Hospital. Results All patients underwent operation, including 31 radical mastectomy , 25 modified radical mastectomy and 3 simple mastectomy. 34 cases had axillary lymph node metastasis. The overall 3,5 and 7 year survival rates were 67.2% , 61.0% and 57.1%respectively. The 3,5 year survival rates in patients with axillary-lymph node metastasis were lower than those in patients without axillary lymph node metastasis (61.8%,45.5%vs 86.4% ,83.3%). The 3,5 year survival rates in patients with negative C erbB 2 expression were 84.6%,82.4% and in patients with positive C erbB 2 expression were 54.6%,45.8%,respectively(all P
ABSTRACT
Objective To study the expression of cyclooxygenase-2(COX-2) in pancreatic tissues of severe acute pancreatitis(SAP) in rats,and explore the possible role of COX-2 in the pathogenesis of the SAP. Methods Forty adult male Sprague-Dawley rats were randomly divided into SAP group(n=20) and control group(n=20). At 12h after operation,acites,serum levels of amylase activity,tumor necrosis factor-?(TNF-?),TXB 2 and 6-keto-PGF 1? and the expression of COX-2 in pancreatic tissue were detected.the pathological changes of pancreatic tissues were observed and scored under microscope;the survival rate in 72h and mortality in 24h in SAP and NC group were recorded.Results At 12h after the induction of SAP,the serum amylase activity,TNF-?,TXB 2 and 6-keto-PGF 1? were significantly higher in SAP group than those in NC group(P